Abstract
AbstractThis study developed a method of synthesizing distal amino acid derivatives by the ring‐opening reaction of cyclic ketones, following the amino esterification functionalization of both terminals. To achieve this goal, we performed the ring‐opening reaction of cyclic ketones with an aminating reagent and alcohol under metal‐ and photocatalysis‐free conditions in a single step. The method directly afforded distal amino acid derivatives bearing C4−C6, C8, and C12 carbon main chains, such as γ, δ, and ϵ‐amino esters. The obtained amino esters were simply transformed into amino acids by hydrolysis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
