Abstract
The first examples of ring-closing metathesis reactions with allylphosphonamides 1, vinylphosphonamides 2, and vinylphosphonates 8 using the Grubbs ruthenium catalyst 3 are described. These RCM reactions lead to the 6-membered allylphosphonamides 4, the 5-membered vinylphosphonamides 5, and various 5-, 6- and 7-membered phosphonates 9–10. The yield, rate and mode of metathesis in these reactions are sensitive to simple olefin and nitrogen substitution. The first examples of ring-closing metathesis reactions with allylphosphonamides 1, vinylphosphonamides 2, and vinylphosphonates using the Grubbs ruthenium catalyst 3 are described. These RCM reactions lead to 6-membered allylphosphonamides 4, 5-membered vinylphosphonamides 5, and various 5–7 membered cyclic phosphonates. The yield, rate and mode of metathesis are sensitive to simple olefin and nitrogen substitution. [Display omitted]
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