Abstract
Glycosylated poly(phenyl isocyanide)s were synthesized in an attempt to elucidate the effect of three-dimensionally regulated saccharide arrays along highly stereoregular polymer backbones on molecular recognition. Poly(phenyl isocyanide)s substituted with α-d-glucose, β-d-glucose, β-d-galactose, and β-lactose were obtained by polymerization of the corresponding acetylated glycosyl phenyl isocyanides with a Ni(II) catalyst and subsequent deacetylation. Helical main chains and spatially regulated saccharide arrays of the poly(phenyl isocyanide)s were demonstrated by CD spectroscopy and molecular dynamics calculations. Their binding affinity with lectins was investigated by inhibition of hemagglutination and fluorescence spectroscopy. The rigid cylindrical phenyl isocyanide glycopolymers exhibited little specific interactions with lectins, which was in contrast to the highly specific interactions of the multivalent glycoclusters along flexible phenylacrylamide glycopolymers. It has been demonstrated that th...
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.