Abstract
Rigid DNA Beams for High‐Resolution Single‐Molecule Mechanics
Highlights
Single molecule mechanical techniques like AFM or optical tweezers provide insight into the conformational dynamics of macromolecules and allow reconstructing details of the free energy landscapes that direct such processes.[1]
In a typical single-molecule mechanical assay, the molecule of interest is attached to a sensitive probe such as two
F) Histogram of the deflection states visited at a load of approximately 14 pN as measured with the conventional doublestranded DNA (dsDNA) versus the ten-helix bundles
Summary
Single molecule mechanical techniques like AFM or optical tweezers provide insight into the conformational dynamics of macromolecules and allow reconstructing details of the free energy landscapes that direct such processes.[1]. Inset: force-extension response of an eight-helix-bundle linker at different values of trap stiffness.
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