Abstract
Background Movement abnormalities in the left ventricle (LV) were shown to be not really frequent in thalassemia major (TM) patients but they were associated with age, myocardial iron overload, LV dilation and dysfunction, and myocardial fibrosis. No data are available about the prevalence and the correlates of right ventricular (RV) wall motion abnormalities. This study investigated the relationship between RV and LV motion abnormalities and between RV motion and function in a large cohort of well-treated TM patients. Methods CMR was performed in 1092 TM patients (537 male; 30.6 ± 8.5 years) enrolled in the Myocardial Iron Overload in Thalassemia (MIOT) Network. Cine images were acquired to evaluate wall motion and to quantify RV volumes and ejection fraction (EF). Results
Highlights
Movement abnormalities in the left ventricle (LV) were shown to be not really frequent in thalassemia major (TM) patients but they were associated with age, myocardial iron overload, LV dilation and dysfunction, and myocardial fibrosis
Abnormal LV motion was not correlated with abnormal right ventricular (RV) motion
Right volumes indexed by body surface area (BSA) were significantly higher in patients with abnormal RV motion while the ejection fraction (EF) was significantly lower
Summary
Antonella Meloni1*, Vincenzo Positano, Sabrina Armari, Giuseppina Secchi, Giancarlo Izzi, Cristina Salvatori, Claudio Ascioti, Gennaro Restaino, Massimo Lombardi, Alessia Pepe. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. 16-19 January 2014
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