Abstract
Right ventricular (RV) dysfunction has been shown to be a major contributor to the adverse outcomes in subjects with heart failure. Few studies evaluating the right ventricle in heart failure subjectshave been carried out in Sub-Saharan Africa. This studywas therefore designed to evaluate the right ventricular systolic function in subjects with heart failure secondary to hypertensive heart disease presenting to the University College Hospital, Ibadan Nigeria. Seventy-six subjects with heart failure secondary to hypertension and 92 normal controls underwent clinical, electrocardiographic and echocardiographic evaluation. Indices of right ventricular systolic function that were measured include tricuspid annular plane systolic excursion (TAPSE), tissue Doppler derived tricuspid peak systolic lateral annulus velocity(S') and right ventricular fractional areachange(RVFAC). Sixty-two (81.6%) heart failure subjects had right ventricular systolic dysfunction, 31(40.8%) had abnormal TAPSE, 42(55.5%) had abnormal S' while 49(64.5%) had abnormal RVFAC. Elevated pulmonary artery systolic pressure was found in 25(32.9%) of the subjects. There was no relationship between the indices of right ventricular systolic function and the estimated systolic pulmonary artery pressures. The independent predictor of right ventricular systolic dysfunction was the right atrial size. Right ventricular systolic function is impaired in patients with heart failure secondary to hypertensive heart disease. There is no relationship between the indices of right ventricular systolic function and systolic pulmonary artery pressure. Further studies are needed to assess right ventricular systolic function in Nigerians.
Highlights
Pulmonary hypertension is considered an important con-Heart failure (HF) is a major and growing public health tributor toexercise intolerance in heart failure.[5,6] and sevproblem around the world with a prevalence of more eral studies have reported an inverse relationship between than 23 million worldwide.[1]
Right ventricular systolic function is impaired in patients with heart failure secondary to hypertensive heart disease
There is no relationship between the indices of right ventricular systolic function and systolic pulmonary artery pressure
Summary
Pulmonary hypertension is considered an important con-Heart failure (HF) is a major and growing public health tributor toexercise intolerance in heart failure.[5,6] and sevproblem around the world with a prevalence of more eral studies have reported an inverse relationship between than 23 million worldwide.[1]. Heart failure in Africa is mostly attributed to non-ischaemic factors such as hypertension, valve disorders, idiopathic cardiomyopathy in contrast to western countries where ischaemic heart disease is a major contributor to the aetiology of heart failure.[16] Studies across sub-Saharan Africa have documented hypertension as the commonest aetiology of heart failure in Africans.[17] Local studies done in Nigeria have reported hypertension as the commonest aetiology of heart failure in Nigerians.[18,19,20] This study aimed to evaluate the right ventricular systolic function in subjects with heart failure secondary to hypertensive heart disease and to determine the relation- ship between right ventricular systolic function and estimated systolic pulmonary artery pressure. Few studies evaluating the right ventricle in heart failure subjectshave been carried out in Sub-Saharan Africa This studywas designed to evaluate the right ventricular systolic function in subjects with heart failure secondary to hypertensive heart disease presenting to the University College Hospital, Ibadan Nigeria
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