Abstract
ObjectiveDetermination of right hand digit ratio (2D:4D) in non-habit related oral squamous cell carcinoma (OSCC) and their comparison with age matched healthy control group without history of malignancy to identify the possible genetic association. Materials and method26 male patients with histopathological diagnosis of OSCC (average age 52.65±7.766) without history of tobacco and alcohol consumption participated in the study. Other confounding factors like HPV 16, malnourishment and hormonal disorders were eliminated to establish more possible genetic correlation between 2D:4D and OSCC. Right hand index and ring fingers were measured in linear fashion from the middle point of the most proximal crease up to the tip of the finger using image analyzing software (Leica QWin). The results were compared with age matched control group (53.31±7.434) without family history of malignancy. ResultsThe 2D:4D was significantly higher in the OSCC group (0.9855±0.0262) as compared to the control group (0.9605±0.0216). Seven OSCC patients with family history of malignancy showed slightly higher 2D:4D (0.9864±0.03607) than the other OSCC patients (0.9851±0.0253) but significantly higher than the control group (0.9605±0.02168). 16 male family members from 7 patients with family history of malignancy showed higher 2D:4D (0.9765±0.0184) as compared to the control group (0.9508±0.02484). ConclusionThere is a correlation between 2D:4D and OSCC which could be related to common genetic factors. We believe that digit ratio can be used as a possible putative marker for the screening of patients who are at risk of developing OSCC.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
