Abstract
Background Right atrial (RA) pressure (RAP) and NT-ProBNP-levels are important prognostic factors in pulmonary hypertension (PH). The aim of this study was to investigate if RA volume (RAV), emptying fraction and emptying volume measured with cardiac magnetic resonance (CMR) can be used to predict RAP, and to investigate if these measures are related to NT-ProBNP levels. Furthermore, we aimed to determine if RAV in systemic sclerosis patients with precapillary PH (PHSSc) differs from PH patients without systemic sclerosis (PHnonSSc).
Highlights
Right atrial (RA) pressure (RAP) and NT-ProBNP-levels are important prognostic factors in pulmonary hypertension (PH)
PH was defined as mPAP ≥25 mmHg and PCWP ≤15 mmHg at normal or reduced cardiac output. 11 patients with and 16 patients without Systemic Sclerosis and 35 healthy controls underwent cine cardiac magnetic resonance (CMR) to quantify end-systolic maximum (RAVmax) and end-diastolic minimum (RAVmin) right atrial volume indexed to body surface area
Invasive pressures were measured with right heart catheterization and plasma NT-ProBNP level from venous blood samples
Summary
Right atrial (RA) pressure (RAP) and NT-ProBNP-levels are important prognostic factors in pulmonary hypertension (PH). The aim of this study was to investigate if RA volume (RAV), emptying fraction and emptying volume measured with cardiac magnetic resonance (CMR) can be used to predict RAP, and to investigate if these measures are related to NT-ProBNP levels. We aimed to determine if RAV in systemic sclerosis patients with precapillary PH (PHSSc) differs from PH patients without systemic sclerosis (PHnonSSc)
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