RIFM fragrance ingredient safety assessment, 4-ethylbenzaldehyde, CAS Registry Number 4748-78-1

Abstract

The existing informationsupportsthe use of this material as described in this safety assessment. 4-ethylbenzaldehyde was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, and environmental safety. Data on the read-across analog benzaldehyde (CAS # 100-52-7) show that 4-ethylbenzaldehyde is not expected to be genotoxic and provide a calculated margin of exposure (MOE) >100 for the repeated dose toxicity endpoint. Data on read-across analog 3,4-dimethylbenzaldehyde (CAS # 5973-71-7) provide a calculated MOE >100 for the developmental and reproductive toxicity endpoints. Data on read-across analog cuminaldehyde (CAS # 122-03-2) provided 4-ethylbenzaldehyde a No Expected Sensitization Induction Level (NESIL) of 1100 μg/cm². The local respiratory toxicity endpoint was evaluated using the threshold of toxicological concern (TTC) for a Cramer Class I material; exposure is below the TTC (1.4 mg/day). The phototoxicity/photoallergenicity endpoints were evaluated based on data; 4-ethylbenzaldehyde is not phototoxic/photoallergenic. The environmental endpoints were evaluated; 4-ethylbenzaldehyde was found not to be persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.