Abstract
Groups of mice were infected intravenously with M. tuberculosis and treated with rifampicin (40 mg./kg.) alone, isoniazid (25 mg./kg.) alone or both drugs together.Neither rifampicin nor isoniazid given daily for 12 weeks reduced the populations of tubercle bacilli in lungs and spleen below detectable levels in all the animals, whether treatment was started immediately or delayed for three weeks. On the other hand, when both drugs were given together for the same period the lungs and spleen of all but one of 30 animals appeared to be sterilized of tubercle bacilli.When 40 mg./kg. of rifampicin was given daily or 120 mg./kg. twice weekly for four months no tubercle bacilli could be recovered from lungs or spleen in the 10 mice treated in each group.
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