Abstract
ObjectiveTo determine risk factors for a pathological diagnosis of invasive disease in patients with an initial diagnosis of breast ductal carcinoma in situ (DCIS). MethodsA total of 188 patients with a diagnosis of DCIS by core needle biopsy over an 8-year period from 2004 to 2011 were retrospectively reviewed. A variety of clinical, mammographic and histologic features were correlated with the presence of invasion at excision. ResultsNo statistically significant differences were found between patients with and without invasion in patient age, the presence of calcifications, size of the lesion, nuclear grade, or the presence of necrosis. Risk factors for invasion were a palpable lesion and a mass on mammography. ConclusionPatients with palpable breast lesions or a mass on mammography diagnosed as DCIS on core needle biopsy are at increased risk for invasion at excision.
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