Abstract
The aim of this study is to provide preliminary retrospective evidence concerning the histologic and histomorphometric outcome of a novel freeze-dried equine-derived bone paste (EDEBEX) for ridge preservation of sockets following tooth extraction. This pilot retrospective case series describes the histologic and histomorphometric outcome of three patients who received the equine-derived bone paste in post-extractive sockets to allow the preservation of the alveolar ridge. Patients were later rehabilitated with monolithic-zirconia, implant-supported prostheses. All patients healed uneventfully. The collected biopsies showed a prevalence of bone formation at 4 months, compact lamellar bone, with well-defined lamellae surrounding Haversian and Volkmann's canals at 6 months, and an intermediate degree of maturation in active anabolic phase at 7 months after grafting. The amount of mineralized matrix was 63.3-70.7%, whereas medullar spaces were 26.0-30.7%. Histologic examination showed that the bone paste was fully biocompatible. Bone regeneration occurred within the first 4 months from grafting, with 63.3-70.7% mineralized bone matrix. The residual biomaterial, when present, did not exceed, on average, 2%. Ridge preservation using bone substitutes as an alternative to autogenous bone is known to be effective. However, available clinical evidence still does not indicate the biomaterial, if any, that should be preferred to carry it out. The equine bone paste used in the present study appears to be a good candidate for further investigation because it is easy to handle in the clinical setting and it displays a good bone formation rate.
Highlights
Abstr ac tAim and objective: The aim of this study is to provide preliminary retrospective evidence concerning the histologic and histomorphometric outcome of a novel freeze-dried equine-derived bone paste (EDEBEX) for ridge preservation of sockets following tooth extraction
EDEBEX for Ridge Preservation: A Pilot Case Series soft tissue regeneration when they are grafted in post-extractive sockets, and gingival healing is achieved by second intention.[23]
All patients were treated according to the principles of ridge preservation, and all had the freeze-dried equine-derived bone paste EDEBEX (Activabone Putty, Bioteck S.p.A., Arcugnano, Italy) grafted in their post-extractive sockets
Summary
Aim and objective: The aim of this study is to provide preliminary retrospective evidence concerning the histologic and histomorphometric outcome of a novel freeze-dried equine-derived bone paste (EDEBEX) for ridge preservation of sockets following tooth extraction. EDEBEX for Ridge Preservation: A Pilot Case Series soft tissue regeneration when they are grafted in post-extractive sockets, and gingival healing is achieved by second intention.[23] Bone pastes fulfill these requirements, as they are user-friendly formats that are easy to handle and capable of holding optimal space-keeping properties when they are hard enough (e.g., when they are moldable). The authors of the present study have been using a freeze-dried version of EDEBEX for some months and have collected additional clinical and histomorphometric evidence concerning its use to achieve ridge preservation This small case series’ aim is to describe these additional results
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