Ricolinostat induces microtubule acetylation and neurite regeneration in cellular models of diabetic and chemotheraphy-induced neuropathy

Abstract

Peripheral nerves have unique regenerative capability, but two questions are still unanswered: what are the underlying mechanisms and why do some patients show higher spontaneous nerve fibers regeneration than others. Here we investigated if microtubule posttranslational modifications (PTMs) impact on neuronal regeneration in in vitro models of small fiber neuropathy (SFN) and predict intra-epidermal nerve fibers regeneration density (IENFD) in patients.