Abstract
Introduction:Obesity, diabetes, and hypertension are common risk factors for chronic kidney disease (CKD). CKD arises due to many pathological insults, including inflammation and oxidative stress, which affect renal function and destroy nephrons. Rice bran (RB) is rich in vitamins and minerals, and contains significant amount of antioxidants. The aim of this study was to evaluate the preventive effect of RB on renal disease risk factors.Methods:Male Wistar rats (±325 g) were divided into two experimental groups to received a high sugar-fat diet (HSF, n = 8) or high sugar-fat diet with rice bran (HSF + RB, n = 8) for 20 weeks. At the end, renal function, body composition, metabolic parameters, renal inflammatory and oxidative stress markers were analyzed.Results:RB prevented obesity [AI (HSF= 9.92 ± 1.19 vs HSF + RB= 6.62 ± 0.78)], insulin resistance [HOMA (HSF= 83 ± 8 vs. HSF + RB= 42 ± 11)], dyslipidemia [TG (HSF= 167 ± 41 vs. HSF + RB=92 ± 40)], inflammation [TNF-α (HSF= 80 ± 12 vs. HSF + RB=57 ± 14), IL-6 (903 ± 274 vs. HSF + RB=535 ± 277)], oxidative stress [protein carbonylation (HSF= 3.38 ± 0.18 vs. HSF + RB=2.68 ± 0.29), RAGE (HSF=702 ± 36 vs. RSF + RB=570 ± 190)], and renal disease [protein/creatinine ratio (HSF=1.10 ± 0.38 vs. HSF + RB=0.49 ± 0.16)].Conclusion:In conclusion, rice bran prevented renal disease by modulating risk factors.
Highlights
Obesity, diabetes, and hypertension are common risk factors for chronic kidney disease (CKD)
Considering that the consumption of high sugar-fat diet can lead to obesity and kidney disease risk factors development and the lack of studies regarding the effect of rice bran on these physiopathological aspects, the aim of this study was to evaluate the effect of rice bran on the modulation of renal disease risk factors in animals submitted to high sugar-fat diet
It is possible to verify reduced homeostatic model of insulin resistance (HOMAIR) and triglycerides in the HSF + Rice bran (RB) group compared to HSF
Summary
Diabetes, and hypertension are common risk factors for chronic kidney disease (CKD). Results: RB prevented obesity [AI (HSF= 9.92 ± 1.19 vs HSF + RB= 6.62 ± 0.78)], insulin resistance [HOMA (HSF= 83 ± 8 vs HSF + RB= 42 ± 11)], dyslipidemia [TG (HSF= 167 ± 41 vs HSF + RB=92 ± 40)], inflammation [TNF-α (HSF= 80 ± 12 vs HSF + RB=57 ± 14), IL-6 (903 ± 274 vs HSF + RB=535 ± 277)], oxidative stress [protein carbonylation (HSF= 3.38 ± 0.18 vs HSF + RB=2.68 ± 0.29), RAGE (HSF=702 ± 36 vs RSF + RB=570 ± 190)], and renal disease [protein/creatinine ratio (HSF=1.10 ± 0.38 vs HSF + RB=0.49 ± 0.16)]. Conclusion: In conclusion, rice bran prevented renal disease by modulating risk factors. Conclusão: Em conclusão, o farelo de arroz preveniu doenças renais através da modulação dos fatores de risco
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