Abstract
Ribonucleotide Reductase (RNR) is the rate-limiting enzyme for the de novo dNTP synthesis, the building blocks of nuclear and mitochondrial DNA. RNR consists of two subunits, encoded by genes Rrm1 and Rrm2/Rrm2b. RNR activity is controlled by relative dNTP levels to maintain balanced nuclear and mitochondrial dNTP pools. The Rrm2 acts as a molecular switch that affects RNR activity, dNTP synthesis, and DNA replication. Previous work showed that reduced perinatal RNR activity caused cardiac dilation and early death.
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