Abstract
MS2 protein and MS2 RNA can interact in vitro to form two different types of ribonucleoprotein complex, termed complex I and complex II. Apparently, complex I is composed of one molecule of RNA and a small number (probably not more than six) of protein molecules. It has a sedimentation coefficient very close to that of free RNA. The formation of complex I seems to be a specific process, and MS2 RNA cannot be substituted by other RNA's such as Escherichia coli ribosomal RNA, E. coli transfer RNA, polyadenylic acid, or polyuridylic acid. In electron micrographs, complex II appears as particles which are nearly spherical and have a dimension and shape similar to those of the MS2 virus. However, it is not infectious, nor can it adsorb to the normal host of MS2 virus. It has a slightly lower sedimentation coefficient than MS2 virus.
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