Abstract
The ribonuclease of milk has not been investigated, although there has been in recent years a rapid expansion of our knowledge of ribonuclease in body fluids such as cerebral spinal fluid ( Houck, 1958), blood ( Levy and Rottino, 1960; Rabinovitch and Dohi, 1957; Zittle and Reading, 1945), urine ( Levy and Rottino, 1960), and the extracellular fluid of skin ( Tabachnick and Freed, 1961). Zittle and DellaMonica (1952) noted that certain purified fractions of bovine milk showed phosphodiesterase activity when ribonucleic acid was used as the substrate. Bailie and Morton (1958) showed that the nucleic acid content of mammary gland microsomes diminished when the microsomes were incubated in milk serum for 12 hours, and suggested that the phosphodiesterase of Zittle and DellaMonica (1952) might have caused the decrease in nucleic acid. They suggested that milk microsomes (with a low nucleic acid content) might be derived from mammary gland microsomes, which contained a much higher nucleic acid content. In this report evidence is presented for the presence of relatively high concentrations of ribonuclease in cow's milk. Some properties of this enzyme, as well as its partial purification, are described.
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