Abstract
Nutritional status of essential fatty acid (EFA) deficient rats with regards to riboflavin was evaluated. D-Amino acid oxidase activity in livers of rats fed EFA deficient diet was significantly reduced. Essential fatty acid deficiency did not have any effect on the total riboflavin content in the kidneys and livers, but there appeared to be a reduction in flavin mucleotide concentration in kidney. Increasing the riboflavin content of the EFA deficient diet was not effective in restoring the enzyme activity. Realimentation of EFA deficient rats with safflower oil alone increased the enzyme activity in liver and the flavin nucleotides in kidney to levels found in control rats. It is suggested that the reduction observed in D-amino acid oxidase activity in EFA deficiency could be due to a decreased synthesis of flavin nucleotides from free riboflavin and/or to increased hydrolysis of flavin adenine dinucleotides.
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