Abstract
Erythrocyte glutathione reductase (GR) activity of the neonate in the first and second days of life is elevated twofold over that of adults and is unrelated to intracellular concentrations of GSH, FAD, riboflavin plus FMN, or total flavin. These findings are similar to those reported in erythrocytes of cord blood. The conversion of GR from the inactive to the active form by in vitro FAD has been shown to be a useful index of riboflavin deficiency in adults and in older children, but is shown in this study to be rapidly changing during these first days of life.
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