Abstract
Two new phthalide derivatives, rhytidhylides A (1) and B (2), together with ten known compounds (3–12) were isolated from cultures of Rhytidhysteron sp. BZM-9, an endophyte isolated from the leaves of Leptospermum brachyandrum. Their structures were identified by an extensive analysis of NMR, HRESIMS, ECD, and through comparison with data reported in the literature. In addition, the cytotoxic activities against two human hepatoma cell lines (HepG2 and SMMC7721) and antibacterial activities against MRSA and E. coli were evaluated.
Highlights
Endophytic fungi plays a role in supplying plants with the basic nutrients indispensable for their growth and helping them in the mechanisms of adaptation to various environmental stresses, but they can produce various bioactive natural products [1]
During our search for new bioactive, secondary metabolites of fungi isolated from various medicinal plants, the strain Rhytidhysteron sp
BZM-9 was obtained and identified, which was isolated from Leptospermum brachyandrum
Summary
Endophytic fungi plays a role in supplying plants with the basic nutrients indispensable for their growth and helping them in the mechanisms of adaptation to various environmental stresses (i.e., salinity, drought), but they can produce various bioactive natural products [1]. Widely found in several higher and lower plant and fungal genera, is a naturally occurring benzobutyrolactones [2]. Many of the naturally occurring phthalides display different biological activities including antibacterial [3], antifungal [4], insecticidal [5], cytotoxic [6], and antioxidant [7] effects, which has attracted widespread attention from other researchers. During our search for new bioactive, secondary metabolites of fungi isolated from various medicinal plants, the strain Rhytidhysteron sp. In the course of our continued search for bioactive compounds from endophytes, two new phthalide derivatives, rhytidhylides A (1) and B (2), along with ten known compounds (3–12), were isolated from cultures of Rhytidhysteron sp.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
