Rhythmic temporal coordination of neural activity prevents representational conflict during working memory

Abstract

Selective attention1 is characterized by alternating states associated with either attentional sampling or attentional shifting, helping to prevent functional conflicts by isolating function-specific neural activity in time.2,3,4,5 We hypothesized that such rhythmic temporal coordination might also help to prevent representational conflicts during working memory.6 Multiple items can be simultaneously held in working memory, and these items can be represented by overlapping neural populations.7,8,9 Traditional theories propose that the short-term storage of to-be-remembered items occurs through persistent neural activity,10,11,12 but when neurons are simultaneously representing multiple items, persistent activity creates a potential for representational conflicts. In comparison, more recent, "activity-silent" theories of working memory propose that synaptic changes also contribute to short-term storage of to-be-remembered items.13,14,15,16 Transient bursts in neural activity,17 rather than persistent activity, could serve to occasionally refresh these synaptic changes. Here, we used EEG and response times to test whether rhythmic temporal coordination helps to isolate neural activity associated with different to-be-remembered items, thereby helping to prevent representational conflicts. Consistent with this hypothesis, we report that the relative strength of different item representations alternates over time as a function of the frequency-specific phase. Although RTs were linked to theta (∼6Hz) and beta (∼25Hz) phases during a memory delay, the relative strength of item representations only alternated as a function of the beta phase. The present findings (1) are consistent with rhythmic temporal coordination being a general mechanism for preventing functional or representational conflicts during cognitive processes and (2) inform models describing the role of oscillatory dynamics in organizing working memory.13,18,19,20,21.