Abstract
Autoregulation of nephron blood flow involves two oscillatory processes: the tubular-flow sensitive tubuloglomerular feedback (TGF) mechanism and the blood-pressure sensitive myogenic mechanism. Both act to regulate the diameter of the afferent arteriole, which carries blood to the nephron. In this paper, we apply wavelet analysis to time series of the proximal tubular pressure obtained from normotensive and hypertensive rats to study how the TGF-mediated oscillations modulate both the frequency and the amplitude of the myogenic oscillations. The tubular pressure oscillations are nearly periodic for normotensive rats, but irregular (or chaotic) for rats with hypertension. Modulation phenomena are clearly observed in both types of rats, but the effect is stronger in those with hypertension.
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