Abstract
Retinal alterations have recently been associated with numerous neurodegenerative diseases. Rhodopsin is a G-protein coupled receptor found in the rod cells of the retina. As a biomarker associated with retinal thinning and degeneration, it bears potential in the early detection and monitoring of several neurodegenerative diseases. In this review article, we summarize the findings of correlations between rhodopsin and several neurodegenerative disorders as well as the potential of a novel technique, cSLO, in the quantification of rhodopsin.
Highlights
Neurodegenerative disease is a major problem faced by an aging population around the world (Prince et al, 2013)
Rhodopsin has emerged as a biomarker, which may serve as the link between retinal thinning and neuronal pathology seen in neurodegenerative diseases
The unfolded protein response occurs neurodegenerative disorders, but is activated as a part of the normal aging process, which is marked by an increase in oxidative stress and the pro-inflammatory state (Lenox et al, 2015)
Summary
Neurodegenerative disease is a major problem faced by an aging population around the world (Prince et al, 2013). Rhodopsin has emerged as a biomarker, which may serve as the link between retinal thinning and neuronal pathology seen in neurodegenerative diseases. One study has found a correlation between the thinning of the retinal nerve fiber layer (RNFL) and retinal ganglion cell degeneration leading to the progression of Alzheimer’s disease (Javaid et al, 2016).
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