Rhodium‐Catalyzed Oxidative ortho‐Acylation of Aryl Ketone O‐Methyl Oximes with Aryl and Alkyl Aldehydes

Abstract

AbstractThe rhodium‐catalyzed oxidative ortho‐acylation of aryl ketone O‐methyl oximes with aryl and alkyl aldehydes via CH bond activation is described. The cross‐coupling reaction exhibits high functional group tolerance and regioselectivity under relatively mild conditions and constitutes a versatile route to a diverse library of diaryl ketones, which are difficult to obtain by the classical Friedel–Crafts acylation. Moreover, this reaction proceeds via an unprecedented Rh‐catalyzed oxidative ortho‐acylation of aryl ketone O‐methyl oximes with highly electron‐deficient aryl aldehydes followed by a direct addition of the second ortho CH bond to aldehydes in a one‐pot reaction, to generate two CC bonds simultaneously.