Rhodium-catalyzed intramolecular annulation via C-H activation leading to fused tricyclic indole scaffolds.

Abstract

The rhodium(III)-catalyzed intramolecular annulation of alkyne-tethered acetanilides for the synthesis of fused tricyclic indole scaffolds via C-H activation has been developed, which has the potential for the synthesis of many indole alkaloids. This reaction proceeds under mild reaction conditions and with tolerance to a variety of functional groups.