Abstract
Abstract A novel method for the rhodium-catalyzed C6-selective alkoxycarbonylation of 2-pyridones is developed. This protocol offers a facile and direct synthetic route to 2-pyridone-6-carboxylates, for which C–H functionalization has never been realized. The reaction proceeds without the use of a stoichiometric additive and by using dialkyl dicarbonates as the alkoxycarbonyl source. The protocol can be successfully employed for a large-scale reaction.
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