Abstract
AbstractA rhodium‐catalyzed C(sp2)‐H ethoxycarbonylation of indoles and arylpyridines using diethyl dicarbonate was developed. The catalytic process features an additive‐free ethoxycarbonylation reaction, in which only ethanol and CO2 are produced as byproducts, providing a CO‐free and operationally simple protocol. The introduced ethoxycarbonyl group is easily transformed into other ester and amide functionalities in a single step. Moreover, the reaction can be successfully applied on gram scale, and allows for the efficient synthesis of indole‐2‐carboxylic acid esters and isophthalates.
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