Abstract
A rhodamine-2-thioxoquinazolin-4-one derivative (R1) has been synthesized by an addition-elimination reaction of rhodamine 6G ethylenediamine with methyl 2-isothiocyanatobenzoate, which exhibits high selectivity and sensitivity as a fluorescent sensor toward Fe3+ under physiological conditions. Moreover, R1 could sense Fe3+ by “naked eye” with a color change from colorless to yellow. To test the practical use of the probe, the determination of Fe3+ in real water samples was evaluated. The application of the fluorescent sensor in monitoring intracellular Fe3+ in glioma cell line U251 has also been demonstrated. In addition, single crystal structures of R1·1·5H2O·0·5CH3CN, as well as the possible intermediate of R1 with Ag+ and Hg2+ ions were reported.
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