Abstract
Publisher Summary This chapter discusses Rho guanosine 5'-triphosphates (GTPases) and cell migration-fibroblast wound healing. The chapter describes various methods for analyzing the roles of the Rho GTPases in regulating distinct parameters of cell migration. Cell migration is critical for many natural biological processes, including embryonic morphogenesis, wound healing, and host defense against infections. Migrating cells in culture display three types of dynamic actin structure: lamellipodia and filopodia, which are sheet and finger-like protrusions at the leading edge of the cell, and contractile actin-myosin filaments or stress fibers, which traverse the cell from front to back. The Rho family of proteins plays a key role in regulating the assembly of actin structures within cells. The three well-characterized members of this family are Cdc42, Rac, and Rho. The chapter concludes with a discussion of the time-lapse imaging of wound edge cells.
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