Abstract
Alkyl 3-oxobutanoates (alkyl: methyl, ethyl, allyl, isobutyl, t-butyl) were reduced enantioselectively to the corresponding ( S)-alcohols by the fungus Rhizopus arrhizus and other Rhizopus sp. The best result obtained was with t-butyl 3-oxobutanoate, which was reduced by R. arrhizus with 99% enantiomeric excess and ∼68% isolated yield.
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