Abstract
SummarySix compounds in a series of 3-substituted triazinoindoles were tested for inhibitory activity against a large number of rhinovirus strains. All of the compounds produced some inhibition of rhinovirus growth as measured by the suppression of viral CPE in WI-38 cell culture tubes. Two of the compounds, 2,2-dimethyl-3-[(5-methyl-5H-as-triazino [5,6-b | indole-3-yl)amino]-1-propanol (SK&F 28938) and 2-methyl-4-| (5-methyl-5 H-as-triazino [5,6-b] indole-3-yl)amino|-2-butanol (SK&F 30097), with paired methyl groups in the side chains were the most active. In gradient plate plaque reduction experiments using HeLa cells, SK&F 30097 had a minimum inhibitory capacity for rhino-viruses ranging from 21 to 32 μM (6–9 μg/ml). HeLa cell morphology was not altered by SK&F 30097 at a concentration of 350 μM (100 μg/ml). The mechanism of the antiviral action of the 3-substituted triazinoindoles is currently unknown.
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