Abstract
Cystic fibrosis (CF) is a multisystem disease that can have significant sinonasal manifestations. Viscous secretions are one of several factors in CF that result in chronic sinonasal pathology, such as sinusitis, polyposis, congestion, and obstructive crusting. Persistent discomfort and nasal manifestations of this disease significantly affect quality of life.
Highlights
Cystic fibrosis (CF) is a systemic, inherited disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene that results in impaired anion transport, affecting the respiratory, exocrine, gastrointestinal, and reproductive tracts [1]
Conservative management with aerosolized nasal steroids, antihistamines, and saline irrigation has been regarded as the initial step in treating chronic sinonasal complaints in CF patients [20]
The use of extended duration empiric antibiotic therapy, both topical and systemic, for these symptoms is concerning, considering the high risk that CF patients have of colonization with multidrug resistant organisms [21]
Summary
Cystic fibrosis (CF) is a systemic, inherited disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene that results in impaired anion transport, affecting the respiratory, exocrine, gastrointestinal, and reproductive tracts [1]. Viscous secretions are one of several factors in CF that result in chronic sinonasal pathology, such as sinusitis, polyposis, congestion, and obstructive crusting. We present one such case and investigate other cases of septal damage secondary to digital trauma, as well as discuss the importance of sinonasal therapy in CF patients.
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