Rhinorrhea related to antipsychotic drug therapy

Abstract

positive (tetanus toxoid and mumps)-Negative candida at 1: 500 and 1: 100. Normal serum protein electrophoresis, liver and thyroid function tests, lactic dehydrogenase, electrolytes, calcium, creatinine, and erythrocyte sedimentation rate. Negative ANA, RF, and HIV-l ELISA. Hematocrit 41.5%, white blood cell count 17,100 with 42% neutrophils, 35% lymphocytes, 7% atypical lymphocytes, 8% monocytes, 8% eosinophils, and a normal platelet count (WBC count was 11,000, with a normal differential 15 months earlier). Repeat WBC count 1 month later was 18 500, with 57% lymphocytes (small and mature appearing on the peripheral smear with associated smudge cells). A diagnosis of chronic lymphocytic leukemia (CLL)stage A was confirmed by hematology/oncology evaluation. The patient remained clinically stable, and after 8 weeks on oral ketaconazole therapy, her nasal candidiasis and sinus symptoms had improved, but not fully resolved. She had, however, developed a symptomatic candidal infection in her right external auditory canal, which was responding to topical antifungal therapy.