Abstract
Rh(III)-catalyzed C–H activation features mild reaction conditions, good functional group tolerance, high reaction efficiency, and regioselectivity. Recently, it has attracted tremendous attention and has been employed to synthesize various heterocycles, such as indoles, isoquinolines, isoquinolones, pyrroles, pyridines, and polyheterocycles, which are important privileged structures in biological molecules, natural products, and agrochemicals. In this short review, we attempt to present an overview of recent advances in Rh(III)-mediated C–H bond activation to generate diverse heterocyclic scaffolds with sp3 carbon centers.
Highlights
Many excellent reviews have summarized the construction of heterocycles by different transition-metal-catalyzed C–H activation were reported, such as Pd [29], Cu [30], Ru [31], Rh [32], Ag [33], and other metals [34,35,36,37,38]
To the best of our knowledge, there is currently no review focus on Rh(III)-catalyzed heterocyclic synthesis with sp3 carbon centers. This mini-review will focus on presenting an overview of advances in Rh(III)-catalyzed C–H activation
In 2017, Loh and co-workers reported a process for the formation of isoindolinone derivatives
Summary
The heterocycle is one of the most important molecular scaffolds and is widely distributed in biological active molecules, agrochemicals, functional materials, and natural products [1,2,3]. The high-speed developing of transition-metal catalyzed C–H bond functionalization in recent years seems to offer a more direct and effective pathway to construct the intriguing heterocyclic scaffolds. Many excellent reviews have summarized the construction of heterocycles by different transition-metal-catalyzed C–H activation were reported, such as Pd [29], Cu [30], Ru [31], Rh [32], Ag [33], and other metals [34,35,36,37,38]. To the best of our knowledge, there is currently no review focus on Rh(III)-catalyzed heterocyclic synthesis with sp carbon centers. This mini-review will focus on presenting an overview of advances in Rh(III)-catalyzed C–H activation. In order to discuss conveniently, these synthetic strategies will be sorted according to the size and type of the heterocycle scaffold
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