Abstract
BackgroundThe risk of periodontitis (PD) is increased in the patient group of rheumatoid arthritis (RA). RA and PD also shared some pathological mechanism. The aim of this study is to investigate the risk of RA associated with PD exposure.Methods and FindingsThis study identified 3 mutually exclusive cohorts using the 1999–2010 Taiwanese National Health Insurance Research Database (NHIRD) to investigate the association between PD and the risk of incident RA. All patients with PD in 2000 were identified from the database of all enrollees as the PD cohort. From the representative database of 1,000,000 enrollees randomly selected in 2010 (LHID2010), individuals without any periodontal disease (PO) during 1999–2010 were selected as the non-PO cohort. Individuals who were not included in the non-PO cohort and received dental scaling (DS) no more than two times per year during 1999–2010 were selected as the DS cohort from LHID2010. Using cox proportional regression analysis, hazard ratios (HRs) with 95% confidence intervals (Cis) were calculated to quantify the association between PD exposure and RA development. In the three-group comparison using the non-PO cohort as reference, we found that the risk of RA was higher in the PD and DS cohorts (HRs, 1.89 and 1.43; 95% CIs, 1.56–2.29 and 1.09–1.87, respectively). For comparisons between two cohorts, the PD cohort had a higher risk of RA than the non-PO and DS cohorts (HRs, 1.91 and 1.35; 95% CIs, 1.57–2.30 and 1.09–1.67, respectively).ConclusionPD was associated with an increased risk of RA development.
Highlights
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease with a clinical presentation of polyarthritis that is sometimes accompanied with extra-articular involvement, such as scleritis, vasculitis, and pleuritis
The aim of this study is to investigate the risk of RA associated with PD exposure
PD was associated with an increased risk of RA development
Summary
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease with a clinical presentation of polyarthritis that is sometimes accompanied with extra-articular involvement, such as scleritis, vasculitis, and pleuritis. Patients with RA are associated with a greater risk of cardiovascular disease than patients with diabetes [1]. PD is a chronic inflammatory disease triggered by oral bacteria, including Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola, which are important pathogenic bacteria of PD that can destroy the supporting tissue of teeth, eventually resulting in tooth loss [7]. Some evidence has indicated that many systemic conditions are linked to PD, such as cardiovascular disease, osteoporosis, and type 2 diabetes mellitus (DM) [9]. The aim of this study is to investigate the risk of RA associated with PD exposure.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
