Abstract
Materials and methods RA patients submitted to hip replacement surgery were recruited. They were matched to a group of primary OP patients for bone mineral density and major clinical fracture risk factors (age, gender, BMI). Trabecular bone microarchitecture was assessed by micro-computed tomography and bone mechanical behavior by compression tests. Bone cell activity was analyzed by studying gene expression.
Highlights
Rheumatoid arthritis (RA) and primary osteoporosis (OP) are associated with bone fragility
Rheumatoid arthritis is associated with increased DKK1 expression and disturbances in the bone turnover regulating genes
In this study we aimed to identify differences in the mechanisms involved in bone fragility by comparing gene expression between RA and OP bone samples
Summary
Joana Caetano-Lopes1*, Ana Rodrigues, Ana Lopes, Ana C Vale, Michael A Pitts-Kiefer, Bruno Vidal, Inês P Perpétuo, Jacinto Monteiro, Yrjö T Konttinen, Maria F Vaz, Ara Nazarian, Helena Canhão1,2†, João E Fonseca1,2†. From 6th European Workshop on Immune-Mediated Inflammatory Diseases Nice, France. From 6th European Workshop on Immune-Mediated Inflammatory Diseases Nice, France. 23-25 November 2011
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