Abstract
Aim: To present the heterotopic ossification of left-sided heart valves due to rheumatic inflammation and biomineralization. Introduction: Calcification in the region of mitral-aortic continuity is significant at its origin and etiopathogenesis. The etiology of valvular calcification may be divided into 3 groups, namely, inflammation, degeneration and metabolic disturbances. Calcification of cardiac valve leaflets is most often due to rheumatic etiology in tropical nations. Case Report: A 52-year-old male developed sudden onset of light-headedness and palpitations due to atrial fibrillation. Transthoracic 2D echocardiography revealed calcification of anterior mitral leaflet and aortic valve which resembles a bone-like structure and the patient was advised double valve replacement. Conclusion: It was known that the cellular mechanisms play an important role in its genesis and therapeutic strategies are targeted to reverse this process by understanding its biological mediators.
Highlights
A calcified valve is the hardening of valve due to the deposition of calcium salts at the site of wear-and-tear and damage
Rheumatic valve calcification is not a random passive process, but it is a regulated, inflammatory cellular process associated with the expression of osteoblast markers and neoangiogenesis
Once the osteoblast activity has been established, the disease progression is more likely to be regulated by the mediators of calcium homeostasis [11]
Summary
A calcified valve is the hardening of valve due to the deposition of calcium salts at the site of wear-and-tear and damage. Calcification is more likely to affect the valves on the left side of the heart (mitral and aortic valves) since they experience greater pressure, more wear-and-tear damage with increased risk of deposition of calcium phosphate salts, known as dystrophic calcification. This senile valve calcification occurs on the mitral valve at the age of 50 - 70 years and on the aortic valve at 70 - 90 years of age. The anterior mitral leaflet-aortic cusp continuity region was affected by this mineralization process and so this case had been reported
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
