RHEUMATIC MANIFESTATION IN HIV PATIENT AND EFFECT OF ART ON IT: SINGLE CENTRED STUDY

Abstract

Background HIV (Human Immunodeciency Virus) infection has now become a chronic illness due to antiretroviral therapy (ART). The prevalence of rheumatic manifestations with disease has been gradual rises. Aim and Objective: Aim of this study was to Find the relation between the rheumatic manifestations and ART drug regimens. This was a Material and methods: cross sectional study carried out on 104 patients of either sex with HIV conrm status attending a tertiary care hospital (Motilal Nehru Medical College and associated hospital). During the study period (June 2020 to August 2021) patients were assessed by clinical examination and with relevant laboratory investigation, to diagnose the rheumatological manifestation, & detailed history of ART therapy and duration of ART therapy. Out of 104 HIV patients 54.8% of the participants were male and 45.2% were Result: male most common rheumatic manifestation was arthritis (65.8%). The mean SD of CD4 count in HIV patients with rheumatic manifestation was 283.12(86.46). This was signicantly lower than HIV patients with no rheumatic manifestation, showed that lower CD4 count increase the incidence of Rheumatic manifestation. Rheumatic manifestation was more in those patients who were on longer duration of ART. There was no signicant difference between ZLN group and TLN group in terms of distribution of rheumatic disease.