Rheology of Synovial Fluid From Patients With Osteoarthritis and the Effects of Viscosupplements on the Rheology of Synovial Fluid

Abstract

Osteoarthritis (OA) is the most common joint disorder associated with aging. It is a degenerative joint disease that is characterized by the breakdown of articular cartilage resulting in joint pain and stiffness. Articular cartilage and synovial fluid are closely linked in providing lubrication, and protective barrier between the ends of the bones. Therefore, damage to articular cartilage may result in modification in rheological properties of the synovial fluid and eventually will have an effect on the performance of the joint. In a diseased joint, the composition of the synovial fluid is changed resulting in deterioration of rheological properties. Synovial fluid becomes less viscous and therefore less effective in lubrication [6].