Abstract
Rheological evaluations of MCC-CMC gels were employed to delineate their properties. It was concluded that the thixotropic nature of MCC-CMC gels depended upon the adsorption of the soluble CMC on the MCC. A certain degree of shear was required to unsheave the microcrystals. However, excessive shear reduced the degree of structuring. MCC-CMC in concentrations of 2.0 percent or higher produced thixotropic gels. CMC was found to be superior to HPMC as a linking polymer. At the concentration studied, alcohol and various glycols increased the viscosity of MCC-CMC gels independently of the viscosity of the adjuvant compound. Formulations containing acetaminophen and calamine in MCC-CMC systems were also evaluated.
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