Abstract
Rheological Study on Crosslinking and Gelation of Amidated Carboxymethylcellulose Solutions
Highlights
Hydrogels are hydrophilic three-dimensional polymer networks that, in spite of the large amount of water entrapped, display mechanical responses that are, in a certain sense, intermediate between those of liquids and solids
The kinetics of the crosslinking process can be described with good accuracy by the time evolution of the linear viscoelastic moduli determined at the same frequency throughout the series of frequency sweeps
Similar profiles are displayed in a log-log graph, as it can be deduced from the examples reported in Fig. 1, where the kinetics detected at two different polymer concentrations (1.0 % and 1.8 %) and frequencies (0.628 and 6.28 rad s–1) are compared
Summary
Hydrogels are hydrophilic three-dimensional polymer networks that, in spite of the large amount of water entrapped, display mechanical responses that are, in a certain sense, intermediate between those of liquids and solids. The rheological properties of the hydrogel-based devices must match the requirements of the various applications, such as scaffolds for tissue engineering, drug delivery systems, cell encapsulation devices and injectable formulations. In the last case both sufficient flowability and proper rheological properties after syringe application must be ensured, in particular fast and substantial structural recovery after shearing, leading to adequate viscoelastic moduli at body temperature[9,10,11,12,13,14]. Thermoreversible hydrogels can intrinsically ensure these requirements in virtue of the sol-gel transition promoted by heating[15,16,17,18,19].
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