Rheological researches on the development of the bigels composition for complex mastopathy therapy

Abstract

Aim. To find gel for organogel as a component of the bigel and substantiate the ratio of organo and hydrophilic phase in the composition of the bigel for the complex treatment of mastopathy. Results . Studies of rheological behavior of the samples (structural-mechanical properties) have been carried out using a rheometerRheolabQC by Anton Paar (Austria) using a coaxial cylinder system C-CC27/SS. The device meets the requirements of the standard ISO 3219. On the basis of the obtained results, the values of the dynamic dilution coefficients of the system have been calculated. Mechanical stability (MS) parameters have been calculated for a more complete characterization of the test specimens. The sample made without the use of organogel in the composition has low structural and mechanical parameters, the type of flow of the system approaches the Newtonian type, which indicates its unfitness for use. The profile of changes in the effective viscosity on the concentration of oranogel has the same dependence, however, the use of the composition Spen 60 and fatty oil of seeds of parsley seeds (15 : 85) provides a higher structural viscosity and generally higher structural and mechanical properties. Conclusions. A comparative assessment of the rheological properties of bigelmodel samples for mastopathytreatment with different contents of hydrophilic fractions and organophases of a gel made by the classical technology of emulsifying of parsley seed oil PEG-40 hydrogenated with castor oil. The gel-forming agent for the organogel fraction was determined – Spen 60. The optimal ratio of hydro- and organophases in the composition of the bigel, which was 65/35 and 70/30 %, respectively, was substantiated.