Abstract
The rheological behavior among factors that are present in Stokes law can be used to control the stability of the colloidal dispersion system. The felodipine lipid polymer hybrid nanocarriers (LPHNs) is an interesting colloidal dispersion system that is used for rheological characteristic analysis. The LPHNs compose of polymeric components and lipids. This research aims to prepare oral felodipine LPHNs to investigate the effect of independent variables on the rheological behavior of the nanosystem. The microwave-based technique was used to prepare felodipine LPHNs (H1-H9) successfully. All the formulations enter the characterization process for particle size and PDI to ascertain the colloidal properties of the prepared nanosystem then use coaxial rotational digital rheometer for rheological evaluation. The outcomes show that all felodipine LPHNs formulations (H1-H9) had a nanosize and homogenous structure that ascertain colloidal features of the nanodispersion system. The rheogram chart indicates that all of the felodipine LPHNs formulations (H1-H9) show pseudoplastic flow (non-Newtonian flow) that have shear-thinning property. The microwave-based method prepares felodipine LPHNs formulations (H1-H9) that show excellent physical texture that ascertains its ability as a technique for the preparation of nanoparticles. All of the felodipine LPHNs formulations (H1-H9) show pseudoplastic flow that supports the physical stability of the nanosystem.
Highlights
The rheological behavior among the factors that are present in Stokes law can be used to control the stability of the colloidal dispersion system
The final mixture that contains hydrophobic and hydrophilic phases according to the concentrations of each ingredient as shown in Table 1, was placed in microwave instrument for less than 15 seconds, a mixture was subjected to magnetic stirring of 1000 rpm to form solution of the colloidal structure of felodipine Lipid/polymer hybrid nanocarriers (LPHNs)
The results of DLS revealed that the mean particle sizes of the felodipine LPHNs formulations were H1 (87 nm), H2 (70nm), H3 (146 nm), H4 (33 nm), H5 (94 nm), H6 (978 nm), H7 (49 nm), H8 (75 nm) and H9 (809nm).The outcomes show that all felodipine LPHNs formulations (H1-H9) had nanosize and ascertain colloidal features of the nanodispersion system[17]
Summary
The rheological behavior among the factors that are present in Stokes law can be used to control the stability of the colloidal dispersion system. Lipid/polymer hybrid nanocarriers (LPHNs) is an interesting colloidal dispersion system that is used for rheological characteristic analysis. This research aims to prepare oral felodipine LPHNs to investigate the effect of independent variables which are lipid content, surfactant mixture and distilled water, on the rheological behavior of the nanosystem. A microwave-based technique was successfully used to prepare felodipine LPHNs (H1-H9). The rheogram chart indicated that all felodipine LPHNs formulations (H1-H9) show pseudoplastic flow (nonNewtonian flow), suggesting a shear-thinning property. The microwave-based method successfully produced felodipine LPHNs with excellent physical texture that proves its ability as a nanoparticles preparation technique. The pseudoplastic flow behavior of felodipine LPHNs formulations (H1-H9) suggests that the described nanosystems in this study are physically stable Keywords: Rheology, Felodipine, Lipid-polymer hybrid nanocarriers, Microwave-based method. للتأكد من الخصائص الغروانية للنظام النانوي المحضر ثم استخدام مقياس الانسياب الرقمي الدوراني المحوري لتقييمPDI لحجم الجسيمات و
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