Abstract
Formulation design of Aceclofenac microcapsules by inotropic gelation technique, characterization studies and release kineticsA. Ashok Kumar, Putta Rajesh Kumar, A.Anil Kumar, K.Lokeswara Reddy, T.E.G.K.Murthy, T.Venkateswara Rao
Highlights
Polysaccharides obtained from bacteria, may accumulate inside the cells displaying storage function such as glycogen, may be present as structural components in the form of a slime layer as capsular polysaccharides e.g. K30 O-Antigen or secreted outside the cells as extracellular bacterial polysachharides or exopolysaccharides (EPS) e.g. xanthan, bacterial alginate, sphingan etc. (Manivasagan and Kim, 2014; Schmid et al, 2015)
The present review article aims to focus on the source, structure and detailed studies on solubility, solution rheology and gelation mechanism of several gelling and non-gelling bacterial exopolysaccharides in aqueous medium
In case of EPS synthesized by Enterobacter aerogenes type 54, containing the same repeat unit of D-glucose, L-fucose and D-glucuronic acid, as that of EPS from strain XM6, the carboxylate groups are shielded by side chains due to the presence of O-acetyl groups on every tetrasaccharide or octasaccharide and the EPS fails to produce gels which are amorphous in nature
Summary
Polysaccharides obtained from bacteria, may accumulate inside the cells displaying storage function such as glycogen, may be present as structural components in the form of a slime layer as capsular polysaccharides e.g. K30 O-Antigen or secreted outside the cells as extracellular bacterial polysachharides or exopolysaccharides (EPS) e.g. xanthan, bacterial alginate, sphingan etc. (Manivasagan and Kim, 2014; Schmid et al, 2015). The present review article aims to focus on the source, structure and detailed studies on solubility, solution rheology and gelation mechanism of several gelling and non-gelling bacterial exopolysaccharides in aqueous medium. Native polysaccharides can be subjected to customized structural modifications through substitutions under controlled reaction conditions These newer derivatives usually possess optimized solubility, rheological characteristics and other tunable properties leading to newer avenues for their novel uses. The present review highlights on recent trends and findings on solubility profile, rheological behavior, reported and expected pharmaceutical possibilities of exopolysaccharides of bacterial origin such as curdlan, levan, Fucogel and sphingans. Some miscellaneous heteropolysaccharides such as succinoglycans and EPS obtained from Lactic acid bacteria have been discussed
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