Abstract
Pterodon pubescens, popularly known as "sucupira", it is traditionally used as anti-inflammatory agent. This work aimed to evaluate the in vivo antiarthritic properties of a P. pubescens oil nanoemulsion and the rheological behavior of the developed system. The viscoelastic properties, creep and recovery were evaluated by dynamic oscillatory tests. The antiarthritic activity of the nanoemulsion was evaluated by the zymozan-induced arthritis model, at three different doses (25, 50 and 125 mg/kg/day). P. pubescens oil nanoemulsion has been shown to decrease cell recruitment to a joint cavity and increased cartilaginous regeneration at the end of treatment of the dose of 50 mg/kg. The evaluation of the behaviour of deformation allowed to observe that the P. pubescens nanoemulsion presents predominantly elastic characteristic. These findings demonstrate the potential of P. pubescens and nanotechnology in the development of new antiarthritic drugs.
Highlights
Rheumatoid arthritis is a chronic inflammatory disease, of autoimmune origin and unknown etiology, characterized by progressive inflammation of the synovial capsule
This work aimed to evaluate the in vivo antiarthritic properties of a P. pubescens oil nanoemulsion and the rheological behavior of the developed system
These findings demonstrate the potential of P. pubescens and nanotechnology in the development of new antiarthritic drugs
Summary
Rheumatoid arthritis is a chronic inflammatory disease, of autoimmune origin and unknown etiology, characterized by progressive inflammation of the synovial capsule. Scientific evidence of the antiinflammatory activity of the hexanic fraction of the hydroalcoholic extract of P. pubescens fruits has already been demonstrated (Hoscheid et al, 2013), formulations from extracts of P. pubescens has demonstrated anti-inflammatory activity (Hoscheid et al, 2017) These results allow a good perspective for the development of pharmaceutical products than can be applied in this field. Previous studies have already shown that this system presents spherical-shaped nanosized micelles, exhibited shearthinning behavior (pseudoplastic flow), allowing the adequate syringeability It was demonstrated the physicochemical stability and biocompatible components for parenteral administration (Hoscheid et al, 2015; Hoscheid et al, 2017). The objective of this work was to evaluate the antiarthritic activity of a NE containing the hexanic fraction of the ethanolic extract of P. pubescens by zymozan-induced arthritis model, as well as to evaluate the rheological behavior of the formulation
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