Abstract
Chemotherapy is a common drug for lung cancer. Nevertheless, the development of drug resistance greatly limits their clinical efficacy. Therefore, to reduce drug resistance, we need to constantly explore new treatments. This study is aimed at determining the role of rhein in the proliferation and metastasis of lung cancer cell. Our study found that rhein significantly inhibits the proliferation and migration of lung cancer cells. Additionally, the mRNA expression and protein levels of Snail, MMP2, and MMP9 are decreasing in lung cancer cells treated by rhein. Our results showed that rhein plays a vital role in proliferation and metastasis of chemosensitive and chemoresistant lung cancer cells, and the mechanism may be related to the Stat3/Snail/MMP2/MMP9 pathway.
Highlights
Lung cancer is one of the most common tumors (11.6% of all cases) and accounts for a higher proportion of tumor deaths (18.4% of all cancer deaths) [1]
Our results showed that rhein have obviously affect in treatment of proliferation and metastasis of chemosensitive and chemoresistant lung cancer cells, and play a role via the Signal transducer and activator of transcription-3 (Stat3)/Snail/MMP2/MMP9 pathway
RPMI-1640 medium, penicillinstreptomycin, 0.25% trypsin-EDTA, fetal bovine serum (FBS), and TRIzol were purchased from Thermo Fisher Scientific (Waltham, MA, USA). 3-[4,5-Dimethylthiazol-2-yl]2,5-diphenyltetrazolium bromide (MTT) was purchased from Solarbio Science & Technology (Beijing, China). iScriptTM cDNA Synthesis Kit and SsoFast EvaGreen Supermix were purchased from Bio-Rad Laboratories (Hercules, CA)
Summary
Lung cancer is one of the most common tumors (11.6% of all cases) and accounts for a higher proportion of tumor deaths (18.4% of all cancer deaths) [1]. The main treatments for lung cancer are still surgery, radiotherapy, and chemotherapy. Most lung cancer patients are in the advanced stages of the disease, and surgical treatment is no longer the best option. Chemotherapy and targeted therapies have become the first choice of treatment [2]. Due to the continuous optimization of treatment regiments and the use of targeted drugs, the treatment effect of lung cancer has been significantly improved. Gefitinib and Taxol are considered as effective drugs in the treatment of lung cancer [3,4,5]. In order to improve the quality of life and treatment effect of lung cancer patients, we should explore new therapeutic therapies
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