Rhabdomyosarcoma of the Urinary Bladder Occurring in an Adult

Abstract

A 78-year-old female was referred to urology for hematuria and dysuria. Her urine culture was negative, however, urine cytology showed malignant cells with scant cytoplasm and stippled chromatin (Fig. 1). They were negative for pancytokeratin, CD45, and Melan A, thus making carcinoma, lymphoma or melanoma unlikely. Additional tissue procurement was requested. Cystoscopy revealed a 6 cm bladder mass composed of a small, blue cell tumor, with involvement of the muscularis propria. The tumor expressed skeletal muscle markers (desmin and myogenin) consistent with rhabdomyosarcoma (Fig.