Abstract
Summary A clinicopathologic study was made of 75 patients, 15 years of age and younger, with rhabdomyosarcoma; 60 are dead; 9 have been living for 5 or more years and are apparently free of disease, while 4 have been living free of disease for periods ranging from 2 months to 31/2 years, and 2 are alive with uncontrolled metastasis. When practicable, ablative surgery appears to be the most effective treatment. When radical surgery is not feasible, irradiation combined with chemotherapy and as wide a surgical removal as possible seems to be the best alternative for control of the primary lesion. The chemotherapeutic agent most frequently used in this series was dactinomycin. Survival for 2 years after definitive treatment without evidence of recurrent or metastatic tumor is a reasonably good indication that the child may be cured.
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