Abstract
The [Rh 2{(2 S)-mepy} 4]-catalyzed cyclopropenation of propargylamines carrying two carboxyl or sulfonyl protecting groups with ethyl diazoacetate proceeds in high yield and with enantioselectivities in the range of 90–>97% ee. Selective deprotection of the TEOC-derivative afforded ethyl 2-aminomethylcycloprop-2-ene-1-carboxylate which was converted to several analogs of γ-aminobutyric acid (GABA) containing the cyclopropene or cyclopropane ring.
Published Version
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