Abstract
A Rh(III)-catalyzed annulation of 2-arylimidazo[1,2-a]pyridines with p-quinols has been realized, leading to bridged heterocycles with three contiguous stereocenters via a twofold conjugate addition. The cascade reaction is diastereoselective and proceeds through a sequential Rh-catalyzed ortho C(sp2)-H functionalization of the aryl group of imidazo[1,2-a]pyridine with p-quinol followed by an intramolecular conjugate addition to provide a series of diverse, novel bridged heterocycles.
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